The essay argues that while the thinking of Martin Heidegger was just one (albeit important) non-Marxist element present within the pattern of Kosík’s Dialectics of the Concrete, the later development of Kosík’s thought, especially the later phase of his work attested in the texts from the 1990’s, made the Czech philosopher a Heideggerian thinker and, in a certain sense, a traditionalist whose “critical thinking” simply incorporated some Marxist elements. The essay examines the discrepancies to be found in such an attempt (...) to synthesize the traditionalist thought with the emancipatory aiming of a politically progressive line of thought and especially the tension between Kosík’s democratism and the traditionalist hierarchical ontology. (shrink)

O lidský svět -- Samomluvy a rozhovory -- Malé řeči sváteční -- Doplňky 1 -- Doplňky 2.

This book presents an up-to-date, unified treatment of research in bounded arithmetic and complexity of propositional logic, with emphasis on independence proofs and lower bound proofs. The author discusses the deep connections between logic and complexity theory and lists a number of intriguing open problems. An introduction to the basics of logic and complexity theory is followed by discussion of important results in propositional proof systems and systems of bounded arithmetic. More advanced topics are then treated, including polynomial simulations and (...) conservativity results, various witnessing theorems, the translation of bounded formulas (and their proofs) into propositional ones, the method of random partial restrictions and its applications, direct independence proofs, complete systems of partial relations, lower bounds to the size of constant-depth propositional proofs, the method of Boolean valuations, the issue of hard tautologies and optimal proof systems, combinatorics and complexity theory within bounded arithmetic, and relations to complexity issues of predicate calculus. Students and researchers in mathematical logic and complexity theory will find this comprehensive treatment an excellent guide to this expanding interdisciplinary area. (shrink)

Changes in the shape and structural organization of the cell nucleus occur during many fundamental processes including development, differentiation and aging. In many of these processes, the cell responds to physical forces by altering gene expression within the nucleus. How the nucleus itself senses and responds to such mechanical cues is not well understood. In addition to these external forces, epigenetic modifications of chromatin structure inside the nucleus could also alter its physical properties. To achieve a better understanding, we need (...) to elucidate the relationship between nuclear structure and material properties. Recently, new approaches have been developed to systematically investigate nuclear mechanical properties. These experiments provide important new insights into the disease mechanism of a growing class of tissue‐specific disorders termed ‘nuclear envelopathies’. Here we review our current understanding of what determines the shape and mechanical properties of the cell nucleus. BioEssays 30:226–236, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

In this paper we study abstract elementary classes of modules. We give several characterizations of when the class of modules A with is abstract elementary class with respect to the notion that M1 is a strong submodel M2 if the quotient remains in the given class.

Proof complexity is a rich subject drawing on methods from logic, combinatorics, algebra and computer science. This self-contained book presents the basic concepts, classical results, current state of the art and possible future directions in the field. It stresses a view of proof complexity as a whole entity rather than a collection of various topics held together loosely by a few notions, and it favors more generalizable statements. Lower bounds for lengths of proofs, often regarded as the key issue in (...) proof complexity, are of course covered in detail. However, upper bounds are not neglected: this book also explores the relations between bounded arithmetic theories and proof systems and how they can be used to prove upper bounds on lengths of proofs and simulations among proof systems. It goes on to discuss topics that transcend specific proof systems, allowing for deeper understanding of the fundamental problems of the subject. (shrink)

Computer simulations can be useful tools to support philosophers in validating their theories, especially when these theories concern phenomena showing nontrivial dynamics. Such theories are usually informal, whilst for computer simulation a formally described model is needed. In this paper, a methodology is proposed to gradually formalise philosophical theories in terms of logically formalised dynamic properties. One outcome of this process is an executable logic-based temporal specification, which within a dedicated software environment can be used as a simulation model to (...) perform simulations. This specification provides a logical formalisation at the lowest aggregation level of the basic mechanisms underlying a process. In addition, dynamic properties at a higher aggregation level that may emerge from the mechanisms specified by the lower level properties, can be specified. Software tools are available to support specification, and to automatically check such higher level properties against the lower level properties and against generated simulation traces. As an illustration, three case studies are discussed showing successful applications of the approach to formalise and analyse, among others, Clark’s theory on extended mind, Damasio’s theory on core consciousness, and Dennett’s perspective on intertemporal decision making and altruism. (shrink)

Terminal kidney patients are faced with lower quality of life, restricted diets and higher morbidity and mortality rates while waiting for deceased donor kidney transplantation. Fortunately, living kidney donation has proven to be a better treatment alternative (e.g. in terms of waiting time and graft survival rates). We observed an inequality in the number of living kidney transplantations performed between the non-European and the European patients in our center. Such inequality has been also observed elsewhere in this field and it (...) has been suggested that this inequality relates to, among other things, attitude differences towards donation based on religious beliefs. In this qualitative research we investigated whether religion might indeed (partly) be the explanation of the inequalities in living donor kidney transplants (LDKT) among non-European patients. Fifty patients participated in focus group discussions and in-depth interviews. The interviews were conducted following the focus group method and analyzed in line with Grounded Theory. The qualitative data analyses were performed in Atlas.ti. We found that religion is not perceived as an obstacle to living donation and that religion actually promotes helping and saving the life of a person. Issues such as integrity of the body were not seen as barriers to LDKT. We observed also that there are still uncertainties and a lack of awareness about the position of religion regarding living organ donation within communities, confusion due to varying interpretations of Holy Scriptures and misconceptions regarding the process of donation. Faith leaders play an important educational role and their opinion is influential. This study has identified modifiable factors which may contribute to the ethnic disparity in our living donation program. We argue that we need to strive for more clarity and awareness regarding the stance of religion on the issue of living donation in the local community. Faith leaders could be key figures in increasing awareness and alleviating uncertainty regarding living donation and transplantation. (shrink)

Der Band enthält Beiträge von Medizinern, Juristen, Philosophen und Naturwissenschaftlern aus Estland, Polen, den Niederlanden und Deutschland zu Themen der Ethik und Wissenschaftstheorie der Medizin. Diese Beiträge sind im Rahmen des «Arbeitskreises für Ethik und Wissenschaftstheorie der Medizin in Ostmitteleuropa» entstanden, der auf einer Kooperationsvereinbarung des Interdisziplinären Zentrums für Ethik der Europa-Universität Viadrina Frankfurt (Oder) und des Instituts für Geschichte und Ethik der Medizin der Universität Halle-Wittenberg beruht. Sie befassen sich u. a. mit der Gesundheitsreform in Polen, Tschechien und Ungarn, (...) mit ethischen Problemen bei Abtreibung, HIV-Infektion, Drogenkonsum, Sterbehilfe und Gentechnik sowie dem Theorie-Praxis-Verhältnis in der Medizin. (shrink)

Der Band enthält Beiträge von Juristen, Medizinern und Philosophen aus Australien, Estland, Polen, Rußland, Tschechien, den U.S.A. und Deutschland zu Themen der Ethik und Wissenschaftstheorie der Medizin. Die Mehrzahl der Beiträge sind von Nachwuchswissenschaftlern des College for Advanced Central European Studies an der Europa-Universität Viadrina erarbeitet worden. Sie wurden im Rahmen der Jahrestagung des Arbeitskreises für Ethik und Wissenschaftstheorie der Medizin in Ostmitteleuropa neben weiteren Beiträgen, die hier zum Abdruck kommen, zur Diskussion gestellt. Der Arbeitskreis beruht auf einer Kooperationsvereinbarung des (...) Interdisziplinären Zentrums für Ethik der Europa-Universität Viadrina Frankfurt (Oder) und des Instituts für Geschichte und Ethik der Medizin der Universität Halle-Wittenberg. Die Beiträge befassen sich u. a. mit der Gesundheitsreform in Polen, mit ethischen und rechtlichen Problemen bei der künstlichen Befruchtung, der Abtreibung, medizinischen Experimenten an Menschen, der Gentechnik, der Patientenautonomie, Außenseitermethoden in der Medizin, dem Patiententestament, dem Todesbegriff, Drogenkonsum, der Sterbehilfe und der Gentechnik. (shrink)

Kann man Jonas als Technikphilosophen lesen? Obgleich Jonas’ Praktische Philosophie, insbesondere sein Spätwerk Das Prinzip Verantwortung und die sich anschließenden Schriften auf der Diagnose eines ›technologischen Zeitalters‹ und eines durch die Technikentwicklung induzierten Epochenbruchs der Menschheitsentwicklung basiert, bleibt sein Technikverständnis doch merkwürdig implizit. Eine systematisch entwickelte Technikphilosophie hat Jonas nicht vorgelegt.

As part of the Dutch national science program “Professional Games for Professional Skills” we developed a stress-exposure biofeedback training in virtual reality for the Dutch police. We aim to reduce the acute negative impact of stress on performance, as well as long-term consequences for mental health by facilitating physiological stress regulation during a demanding decision task. Conventional biofeedback applications mainly train physiological regulation at rest. This might limit the transfer of the regulation skills to stressful situations. In contrast, we provide (...) the user with the opportunity to practice breathing regulation while they carry out a complex task in VR. This setting poses challenges from a technical – as well as from a user-experience perspective. We illustrate how we approach these challenges in our training and hope to contribute a useful reference for researchers and developers in academia or industry who are interested in using biosignals to control elements in a dynamic virtual environment. (shrink)

Some critical reactions hardly give clues to the arguer as to how to respond to them convincingly. Other critical reactions convey some or even all of the considerations that make the critic critical of the arguer’s position and direct the arguer to defuse or to at least contend with them. First, an explication of the notion of a critical reaction will be provided, zooming in on the degree of “directiveness” that a critical reaction displays. Second, it will be examined whether (...) there are normative requirements that enhance the directiveness of criticism. Does the opponent have in circumstances a dialectical obligation to provide clarifications, explanations, or even arguments? In this paper, it is hypothesized that the competitiveness inherent in critical discussion must be mitigated by making the opponent responsible for providing her counterconsiderations, if available, thus assisting the proponent in developing an argumentative strategy that defuses them. (shrink)

Among others, the term problem plays a major role in the various attempts to characterize interdisciplinarity or transdisciplinarity, as used synonymously in this paper. Interdisciplinarity is regarded as problem solving among science, technology and society and as problem orientation beyond disciplinary constraints. The point of departure of this paper is that the discourse and practice of ID have problems with the problem. The objective here is to shed some light on the vague notion of problem in order to advocate a (...) specific type of interdisciplinarity: problem-oriented interdisciplinarity. The outline is as follows: Taking an ex negativo approach, I will show what problem-oriented ID does not mean. Using references to well-established distinctions in philosophy of science, I will show three other types of ID that should not be placed under the umbrella term problem-oriented ID : object-oriented ID, theory-oriented ID, and method-oriented ID. Different philosophical thought traditions can be related to these distinguishable meanings. I will then clarify the notion of problem by looking at three systematic elements: an undesired state, a desired state, and the barriers in getting from the one to the other. These three elements include three related kinds of knowledge: systems, target, and transformation knowledge. This paper elaborates further methodological and epistemological elements of problem-oriented ID. It concludes by stressing that problem-oriented ID is the most needed as well as the most challenging type of ID. (shrink)

Short-circuit evaluation denotes the semantics of propositional connectives in which the second argument is evaluated only if the first is insufficient to determine the value of the expression. Com...

The strength and defects of wave mechanics as a theory of chemistry are critically examined. Without the secondary assumption of wave–particle duality, the seminal equation describes matter waves and leaves the concept of point particles undefined. To bring the formalism into line with the theory of special relativity, it is shown to require reformulation in hypercomplex algebra that imparts a new meaning to electron spin as a holistic spinor, eliminating serious current misconceptions in the process. Reformulation in the curved space–time (...) of general relativity requires the recognition of nonlinear effects that invalidate the practice of linear combination of atomic orbitals, ubiquitous in quantum chemistry, and redefines the electron as a nondispersive wave packet, or soliton. (shrink)

This paper is an attempt to argue that there existed a very prominent view of signs and signification in late sixteenth- and seventeenth-century Europe which can help us to understand several puzzling aspects of baroque culture. This view, called here "pansemioticism," constituted a fundamental part of the baroque conception of the world. After sketching the content and importance of pansemioticism, I will show how it can help us to understand the (from a modern perspective) rather puzzling concept of the polymath, (...) or polyhistor, which constituted the ideal of the baroque scientist. In this context I will also discuss a seventeenth century phenomenon essentially connected with polyhistorism, namely that of the early modem polyhistorical collections, the Wunderkamnmern. Since such a study needs a clearly determined focal point, we will concentrate on the last three quarters of the seventeenth century and will mainly discuss works by German authors of the time. (shrink)

The ArgumentThis paper argues that the New Science, which was seen as essentially a public enterprise, was moreover a major constituent of the public sphere in early modern era. In seventeenth-and eighteenth-century Western Europe the sphere of public experimentation, testing, and discussion related to the new science, manifested, itself as a highly diversified, contested, and complex social field.Two general problems arose in constructing this cultural public sphere: the selection of participants in the debate and the inclusion of a heterogenous public (...) in the experimental scene. National authorities employed diverse policies but none denied the necessity of public debate for testing the validity of experimentations. The public sphere had to create its own conditions of existence by imposing manifold regulations in order to make these public meetings possible and enjoyable. These regulations emphasized common interest and the moral code as the most basic condition for rhe sustenance of the public sphere, thus enhancing self-restraint, tolerance, and politeness on the part of both discussants and participants. The more inclusive and heterogenous the public sphere, the more these norms were required. Thus the sphere of public debate constituted by early modern science implied a civilizing process, quite different from and more encompassing than the one analyzed by Norbert Elias. (shrink)

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecendented in its combination of biology with a ...

The article expands the traditional system of concepts used in deontic logic, in order to allow the inclusion of supererogatory behaviour. This requires the development of a deontic decagon. In addition, it is shown how this decagon can be used to interpret deontic terms, e.g. in Islamic Law.

In the course of an immune response, antibodies undergo affinity maturation in order to increase their efficiency in neutralizing foreign invaders. Affinity maturation occurs by the introduction of multiple point mutations in the variable region gene that encodes the antigen binding site. This somatic hypermutation is restricted to immunoglobulin genes and occurs at very high rates. The precise molecular basis of this process remains obscure. However, recent studies using a variety of in vivo and in vitro systems have revealed important (...) regulatory regions, base motifs that are preferred targets of mutation and evidence that transcription may play an active role in hypermutation. BioEssays 20:227–234, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

Despite his ceaseless efforts to purge his fellow citizens of their unfounded opinions and to bring them to care for what he believes to be the most important things, Plato's Socrates rarely succeeds in his pedagogical project with the characters he encounters. This is in striking contrast to the historical Socrates, who spawned the careers of Plato, Xenophon, and other authors of Socratic dialogues. Through an examination of Socratic pedagogy under its most propitious conditions, focusing on a narrow class of (...) dialogues featuring Lysis and Alcibiades, this book answers the question: "why does Plato portray his divinely appointed gadfly as such a dramatic failure?". (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 33.3 (2000) 298-302 [Access article in PDF] Book Review Rhetoric Retold: Regendering the Tradition from Antiquity Through the Renaissance Rhetoric Retold: Regendering the Tradition from Antiquity Through the Renaissance. Cheryl Glenn. Carbondale and Edwardsville, IL: Southern Illinois UP, 1997. Pp. xii + 235. $19.95 paperback; $49.95 hardback. The past decade has produced a number of collections on women and rhetoric, women in rhetoric, and feminist approaches (...) to rhetoric. Reviewers of these collections have commended their contributions as pioneering works [End Page 298] in a new field while calling for book-length studies offering sustained appraisals of individual women figures and theoretical bases for approaching individual women and rhetorical issues, which must be approached differently if women and feminist issues are to be incorporated into the study of rhetoric. Ethos and audience, intention and identification, agonistic argumentation and collective narrative modes of argumentation--each of these takes on new shadings and nuances when women's practices are examined, and when various feminist theories are employed to assess those practices.Glenn's study is a welcome newcomer, a sustained analysis of rhetorical issues across periods, an analysis developed by spotlighting a series of women figures. Very deliberately, Glenn includes "heroic" figures such as Aspasia and Elizabeth I alongside their "lesser" sisters: the marginalized, until now unheard, and often uneducated women who developed rhetorics within severe restraints. The exposition illuminates a number of points in current feminist theory that are shaping rhetorical studies. Some may fault the selections in Glenn's study, and the inevitable omissions, and some may object that focusing on women's silence is yet another victim narrative. Careful readers, however, will find that the discussion of silence in women's rhetoric deftly reverses the traditional negative connotations: "Silence is perhaps the most undervalued and under-understood traditionally feminine rhetorical site" (175). Silence need not be read simply as "passivity. Silence may take many forms and serve many functions" (176), including "enlightened presence" (177).In "Cartographies of Silence" (The Dream of the Common Language, New York: Norton, 1978), Adrienne Rich writes, Silence can be a plan rigorously executed the blueprint to a life Do not confuse it with any kind of absence. (17) Rhetoric Retold begins and concludes by "mapping the silences" of women's presence in the history of rhetoric, and in the very conception of rhetoric. Like Rich, Glenn defines the subtle complexities of silence and absence: silence can indeed be a plan, rigorously executed. We should not confuse it with any kind of absence. Until recently, most histories of rhetoric have not given much attention to women as individual figures or as practitioners [End Page 299] of distinct rhetorical genres. Quite to the contrary, many histories have simply asserted, without proof or evidence, that women have always been forbidden to study or practice rhetoric. Strong assertions of absence belie the truth intimated by Democritus's rebuke: "A woman must not practice argument. This is dreadful. To be ruled by a woman is the ultimate outrage for a man" (Ancilla to the PreSocratic Philosophers, trans. Kathleen Freeman, Cambridge, MA: Harvard UP, 1983, 103). Glenn's double starting point is the question, who left them out, and why? Their absence from our histories has been one among many sources of their silence. The historiographical discussion happily avoids simple charges of phallocentrism and misogyny and instead looks at how entire systems of culture, within different periods, constructed women's roles and voices. Deep background detail within each historical section provides a welcome context for thinking through complex questions of what is rhetorical among the many women's discourses presented for consideration.Although Glenn's study does not dwell on this point, some of the fault for the omission of women from histories of rhetoric, and evidence of the rigorous deliberateness of that omission, can be found in the robust maleness of eighteenth- and nineteenth-century classical philology, and the neoclassical educational systems it underwrote. The quip in Pope's "Epistle 2: To a Lady" of The Moral Essay, "Nothing so true as once you [Martha... (shrink)

This paper aims to contribute to the attempts to clarify and classify the vague notion of “technosciences” from a historical perspective. A key question that is raised is as follows: Does Francis Bacon, one of the founding fathers of the modern age, provide a hitherto largely undiscovered programmatic position, which might facilitate a more profound understanding of technosciences ? The paper argues that nearly everything we need today for an ontologically well-informed epistemology of technoscience can be found in the works (...) of Bacon—this position will be called epistemological real - constructivism. Rather than realist or constructivist, empiricist or rationalist, Bacon’s position can best be understood as real-constructivist since it challenges modern dichotomies. Reflection upon the contemporary relevance of Bacon could contribute to the expanding and critical discussion on technoscience. In the following I will reconstruct the term “technoscience”. My finding is that at least four different understandings or types of the term “technoscience” co-exist. In a second step, I will analyze and elaborate on Bacon’s epistemological position. I will identify central elements of the four different understandings in Bacon’s work. Finally, I will conclude that the epistemology of technoscience is, indeed, very old—it is the epistemological position put forward by Bacon. (shrink)